Wesker used Uroboros in a last ditch effort to kill his nemesis. The tendrils wrapped around several shards of metal and circuitry before spreading to most of Wesker's upper body, giving him a large, deadly, tentacle like appedange. Endowed by the virus, Wesker attacked Chris and Sheva, all the while exaggerating about natural selection, superior DNA, war and pestilence, and his loathe of the current state of the human race. All of this demonstrated that Wesker's calm, collected, and refined exterior had been completely dissolved, along with the last of his sanity. He made repeated attempts to kill both Chris and Sheva, swinging his large arm in a deadly circular manner and lobbing projectiles forged from his tentacles at both of them while they were separated by the breaking ground of the volcano. After taking much fire from Chris, Wesker's other arm succumbed to the growing infection rate of Uroboros and was also absorbed by the virus. Despite this, he somehow managed to keep the rest of his body intact. Eventually, the fight came to the last surviving platform at the center of the lava river. With a feral shout of Chris' name, Wesker jumped to the platform and prepared for the final portion of the conflict. Wesker was then engaged in battle as both Sheva and Chris impaled him on both parts of his weak points.
However, despite his incredible powers, Wesker was held off by Chris and Sheva, until the ground gave way from under him, causing Wesker to fall into the lava. While Wesker screamed in pain, a helicopter piloted by Jill and
Josh Stone came in to rescue Chris and Sheva. They barely managed to climb the ladder Jill threw to them as the ground under them also gave up and sank into the lava. When they were safely aboard, they looked down upon the sinking Wesker, who became enraged and shouted Chris' name for one last time. Refusing to acknowledge his own mortality, and obsessed with killing Chris Redfield, he used his tentacle-consumed left arm to grab hold of the helicopter and viciously tugged at it in hopes of taking them with him. However, Chris and Sheva fired a pair of
RPG-7 rockets at him as he screamed in anger and pain. The rockets went straight through his head, decapitating him, and the resulting explosion sent out a wave of lava that rocked the helicopter and consumed Wesker's mutated remains. Albert Wesker, the diabolical villain hell-bent on world domination, was finally gone forever, and Chris Redfield and Jill Valentine were free of his influence once and for all.
