After months of hiding in the shadows, Wesker and the H.C.F. -a heavily armed assault force- attacked the Umbrella facility on Rockfort Island, intent on retrieving a sample of the T-Veronica virus by one of Umbrella's chief researchers Alexia Ashford. The t-virus was released in the process when armed conflict with Umbrella's guards took place.
The attack succeeded, especially when the t-virus samples and captive B.O.W's in the laboratory section of the facility broke containment and contaminated the Island. However, Wesker and his men failed to find the missing Alexia. Wesker then went to the Antarctic Research Facility, which had also suffered a t-virus outbreak from infected Rockfort employees fleeing to the facility.
It was here Wesker encountered his former subordinate Chris Redfield (who had arrived seeking his missing sister Claire). Wesker failed to gain a sample of the virus from Alexia, especially when he tried to use his own abilities to force her to surrender one, only to be driven back by Alexia's own abilities. Wesker then left Chris to fight Alexia, and secured a sample of the virus from the retrieved corpse of Steve Burnside. The base started its self-destruct sequence, but Wesker engaged Chris in combat, eager to settle the score. Wesker quickly used his immense strength and speed to gain dominance, with Chris refusing to allow Wesker an easy kill. Wesker was poised to deliver the finishing blow, only for an explosion, caused by the priming self-destruct, to knock a flaming pillar in between the two. Wesker, vowing Chris was lucky and next time they met he couldn't count on luck again, escaped the base as it began to crumble and explode around them. Wesker reached an Organization Submarine and sailed away. While the flaming pillar had badly burned Wesker's face, his burns healed sometime later due to his superhuman regenerative capabilities. It would be eight years later following this incident in which Wesker and Chris would meet each other for a confrontation once again.