Following the fall of Umbrella, Wesker soon proved to be a problem for his Organization superiors. Wesker had always cherished a desire for power, prominence and domination over others, and, seeing Umbrella as power incarnate, used it to hide behind while he made plans of his own. He established a secret organization of his own, using Umbrella's infrastructure retrieved from the Umbrella Caucasus Research Facility, and began recruiting agents such as Jack Krauser into it. When Umbrella folded, and the sanctuary and protection it provided ruined by the surviving Umbrella leaders' constant power struggles, Wesker decided that bringing his new Umbrella to complete fruition was his most necessary goal. He would need to amass much wealth and resources. In order to achieve this, Wesker planned to go down the list of Umbrella's other top rival corporations, sell them samples of Umbrella's viruses they desired, and finance his personal empire. He would keep this agenda secret from his Organization superiors, though they were suspicious.
Wesker began his plot with TriCell (disguised with the name "S"), who had been interested in acquiring a sample of the newly discovered Las Plagas parasitic organism, preferably an advanced Control Plaga developed by Los Illuminados cult leader, Osmund Saddler. Wesker contacted Tricell and struck the deal. He commissioned Ada Wong, his old partner, to once again aid the field portion of the operation, while Wesker himself remained at his hideout and kept in touch with her via digital video feed. All the while, he contacted her for reports and updates in the objective. Wesker was apparently on a deadline to retrieve the sample, and made it his and Ada's most important goal. He also sent Krauser in to help Ada, though they were at conflict. Krauser thought that Ada would betray Wesker and said that neither of them trusted her, and Ada noted in her report that she wondered if Wesker had sent her to keep an eye on Krauser. Nothing suggests which of the two Wesker trusted more, though he considered them both expendable pawns.