Wesker had built a vast array of wealth and resources, and had obtained a sample of every known parasitic and viral agent. However, Wesker's hunger for power did not allow him to be satisfied with material possessions. In conjunction with this, he continued to be flooded with questions regarding Spencer's true motivations regarding B.O.W's. In 2006, he discovered the whereabouts of Spencer, his European castle, from Ricardo Irving who had been told by Patrick, and arranged a meet with Wesker through Ada. Wesker traveled there on the first, stormy night of autumn to find answers, killing all of Spencer's bodyguards. Wesker, not knowing that Spencer had arranged the location leak, fully expected Spencer to be surprised by his arrival, but much to his shock, the old man seemed to actually expect Wesker to arrive. It was then Wesker realized that Spencer had been in control of everything from the start, including Wesker's own actions. Spencer revealed that the development of B.O.W's was only a part of achieving his goal of forcing human evolution through viruses. With the birth of a superior human race, Spencer would make himself a god. Spencer required three things to accomplish his dream: the Progenitor virus as a primary viral base, the Umbrella Corporation for funds, and people who would share his ideals when an advanced race came to be. Much to the surprise of Wesker, Spencer revealed Wesker to be the result of the third necessity.
In a plan called the Wesker Plan, Spencer collected hundreds of children from parents of superior intellect throughout the world. These children were all given the surname Wesker after the project's chief researcher, and Spencer used indoctrination and manipulation to install his values into these children. They were then put in controlled environments all over the world under Umbrella's watchful eye. These unaware children would continue to live their lives and received advanced education with the help of Umbrella. One of these children was eventually sent to Umbrella's training facility. That child was Albert Wesker. Spencer then gave all the Wesker children an experimental virus, Albert's being received through Birkin. However, all but one of Albert Wesker's "siblings" were killed due to the virus. Albert was the only one who was confirmed alive at that point in time, as the location of Alex Wesker was unknown, as he had betrayed Spencer. Unfortunately, now that the truth was revealed, the only thing impeding Wesker's ascenion to Godhood was an old, dying man. Wesker killed Spencer by thrusting his arm through his chest, claiming the right to be a god was now his. He then released his 'creator' and allowed his body to topple over and bleed onto the floor. He looked down upon the corpse of Umbrella's founder and pondered how arrogant Spencer had been for believing he, a weak old man, could be a god.