While Spencer is most notable for his role as the president of the Umbrella Corporation, he was also one of the three scientists that discovered the Progenitor virus. Accompanied by his esteemed colleague and good friend Edward Ashford and prominent researcher James Marcus, Spencer was able to make the ground breaking find on December 4th, 1968. After much experimentation with the virus, Spencer was given a vision for the future of the world, which over the years manifested into "Project Wesker", a top secret Umbrella project that would become the reason for every action Spencer took. While driven by their insights to create a powerful viral biological weapon, Spencer and his colleagues established the Umbrella Corporation. The company appeared to create pharmaceutical products, which was truly meant to disguise their sinister motives. Ashford later died as a result of contracting the Progenitor virus. Around the same time, Spencer hired the well-known architect George Trevor to design a special mansion in the Arklay Mountains.
The estate would serve as a camouflage for a secret research laboratory complex in its basement. After realizing that George may disclose of the secrets of the mansion in the future, Spencer had his wife Jessica and their daughter Lisa kidnapped and used as Progenitor virus test-subjects. George was imprisoned within the walls of the mansion he built. Able to remember most of the traps and passages he created, he managed to escape. However, he could not leave the grounds due to the guards and so hid in the caves below the estate. All known information about him stopped after he ceased writing in his diary in December, some time after falling down a hole, where a grave had been prepared for him by Spencer. Also occurring in that year, Spencer established the Umbrella Management Training Facility for further research of the Progenitor virus, and appointed co-founder James Marcus as the first general manager.
After Marcus successfully created the Tyrant virus by introducing the Progenitor virus to a Leech[1], Spencer began to grow paranoid of Marcus' new found reputation. Ultimately, Spencer ordered Marcus' former apprentices, Albert Wesker and William Birkin, to assassinate him. In the aftermath, Spencer appointed Birkin to take over the Tyrant virus project. Spencer was also left as the sole remaining founding member of the Umbrella Corporation, and easily able to monopolize the company for himself.
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