Wesker,S.T.A.R.S,& Lisa Trevor

Wesker was not expecting Lisa's arrival, believing that S.T.A.R.S. had disposed of her in Jessica's tomb. He managed to incapacitate the creature, saying "Nobody's perfect, not even you, Lisa." He then went up in the elevator, heading back up to the mansion. However, after he left, Lisa rose up from the ground, still not dead. With what little of her mind was left, Lisa had no other goal but to take revenge on the man who experimented on and deformed her. She pursued Wesker up to the mansion, and approached him again in the main hall. Wesker noted that he needed to pick up his pace, as the 'hour glass' was running low. He resolved to find another route, not wishing to waste time with the stubborn Lisa, who he knew would pursue him tirelessly.

Fending off the remaining B.O.W.s, Wesker had several confrontations with Lisa, who continued to note as stubborn and at one point humorously saying "She must like me." He saw why she had been called immortal after all the weaponry he emptied into her and she still got up. Eventually, Lisa unexpectedly turned away from Wesker and walked away, and it seemed she had given up. However, when returning to the main hall, Wesker again saw her, this time hiding behind columns in a corner. She approached him one final time, and Wesker, tired of her stalking, said he would grant her wish for eternal rest. Using his new abilities, Wesker matched the persistence of Lisa, jumping high into the air to avoid her more damaging attacks.
Wesker shot the chandelier above them loose, and lured Lisa under it. She was crushed when it fell, and as Wesker walked out of the main hall, he said "Be a good girl and stay dead this time." He then quickly sprinted through the forest, trying to put as much distance as possible between himself and the mansion before it exploded. When it finally did, taking Lisa with it, Wesker looked back at the burning rubble triumphantly. The scenario served as a metaphorical representation of Wesker's proclaiming of being reborn "like a phoenix emerging from the flame." He saw a new horizon stretch out before him, and thought of how he had risen beyond the human race and "cheated death itself", leaving nothing to oppose him in his quest for power.