Wesker,Chris Redfield and Jill Valentine,

Wesker declared that only one with the true capability of being a god could ever deserve that right. Wesker then stood at the window of Spencer's castle and further pondered this new revelation. Spencer's own arrogance manifested into Wesker himself, who decided to carry out his former master's vision of shaping the world with an new and advanced race of humans. Wesker saw that the influence of a pharmaceutical corporation was not true power and insufficient to bring about the godly status he sought. He therefore discarded Umbrella's inferior power and decided to take over the very plan Spencer himself started, with another pharmaceutical company as his base for enacting the plan. Just then, Wesker's old enemies, Chris Redfield and Jill Valentine, entered Spencer's hiding place. They had been hunting Spencer and Wesker, the last of Umbrella's leadership, under the command of the BSAA, and were given a reliable tip to Spencer's whereabouts. They infiltrated the castle, hoping Spencer would lead them to Wesker, but instead found a dead Spencer with a smiling Wesker. The villain took their sudden arrival as a sign: "The weak would always resist the will of the Chosen." A battle immediately ensued. Using his powers, Wesker overcame the two of them combined, outmatching their gun fire and hand to hand skills.
Tossing aside Jill after she failed to turn a knife on him, Wesker sought his revenge on Chris once and for all. However, before he could deal the finishing blow, Jill sacrificed herself by tackling him out of the window, causing the two of them to fall into the chasm below. The BSAA searched for the bodies for months, but were never successful in recovering them, and the two were marked as deceased. In fact, the two survived and Jill was captured by Wesker. After giving Jill the medical treatment she required, Wesker went back to his alliance with Tricell.